Hyaluronic Acid Knee Injection Singapore
Knee gel injection for knee osteoarthritis with Synolis VA and Synvisc-One
Written by Dr Gerard Ee. Reviewed by Dr Dinesh Sirisena and Dr Edwin Tan. Last medically reviewed 7 November 2026
Hyaluronic acid knee injection at The Clifford Clinic
- Synolis VA or Synvisc-One hyaluronic acid knee gel
- Synolis VA as one 4 ml injection or three 2 ml injections a week apart. Synvisc-One as one 6 ml injection
- Relief starts within a week and usually lasts 6 months or more
- Done by Dr Dinesh Sirisena, Dr Edwin Tan or Dr Gerard Ee
- Done under day surgery at The Clifford Surgery, MediSave and hospital insurance claimable
A stiff, creaky knee that aches on stairs and after long walks is often a knee that has lost its natural lubrication. A hyaluronic acid knee injection puts a cushioning gel back into the joint so it moves more smoothly and hurts less. It takes one short visit and you walk out afterwards.
What is a hyaluronic acid knee injection
Healthy knee fluid is thick and slippery because it is rich in hyaluronic acid. In knee osteoarthritis that hyaluronic acid breaks down, the fluid thins, and the joint starts to grind. A hyaluronic acid knee injection, also called a knee gel injection or viscosupplementation, replaces it with a purified gel injected straight into the knee.
The Clifford Clinic offers two gels. Synolis VA combines high molecular weight hyaluronic acid with sorbitol. The hyaluronic acid cushions and lubricates the joint, and the sorbitol protects the gel from breaking down in the inflamed knee so it lasts longer. Synvisc-One is a cross linked hyaluronic acid gel given as a single injection. Your doctor will advise which gel suits your knee.
Who a knee gel injection helps
A hyaluronic acid knee injection suits you if you have
- mild to moderate knee osteoarthritis
- a knee that feels stiff, dry or creaky
- pain that painkillers or anti inflammatories no longer control, or that you cannot take them for
- a wish to delay or avoid knee surgery
It is not given if there is an infection in or around the knee, or an allergy to hyaluronic acid or sorbitol. Your doctor will tell you honestly if a different injection, or surgery, would serve you better.
Single shot or three injection knee gel course
Synolis VA comes in two forms. A single 4 ml injection gives the full dose in one visit. A course of three 2 ml injections, one week apart, spreads the same treatment over three visits. Synvisc-One is always a single 6 ml injection. Your doctor will recommend the one that suits your knee.
What happens during a hyaluronic acid knee injection
- Consultation. The doctor examines your knee and reviews your X ray or MRI to confirm the stage of osteoarthritis.
- Numbing. Numbing cream is applied to the skin.
- Injection. The gel is injected into the knee joint. The injection itself takes only a few minutes.
- Home. You walk out of the clinic the same day.
A knee injection does not need ultrasound. The knee is a large joint and the doctors place the needle by its landmarks.
After your knee gel injection
Avoid heavy exercise and long periods on your feet for 48 to 72 hours. Normal walking is fine. The knee can feel slightly sore, swollen or warm for a day or two, and this settles on its own. Read more in what to expect after a knee injection.
How long a hyaluronic acid knee injection lasts
Most patients feel the knee easing within three to seven days. The benefit builds to its peak at four to twelve weeks and usually lasts six months or more. In a head to head trial, a single injection of Synolis VA worked as well as Synvisc-One over six months. The injection can be repeated when the effect wears off.
Hyaluronic acid vs PRP vs steroid knee injection
A steroid injection works within days but fades within weeks, and repeated steroid can speed up cartilage loss. Hyaluronic acid gel lubricates the joint and works well for a dry, stiff knee. PRP uses your own platelets to calm the joint and can give relief for 6 to 12 months. Compare every option on the knee injection page, or see PRP knee injection and Conjuran knee injection.
Knee gel injection cost, MediSave and insurance
Your fee is quoted at your consultation, after the doctor has examined your knee. Hyaluronic acid knee injections are done under day surgery at The Clifford Surgery and are MediSave and hospital insurance claimable. The team confirms your eligibility and gives you a written estimate before treatment.
Hyaluronic acid knee injection doctors
Hyaluronic acid knee injections at The Clifford Clinic are done by a sports physician, an orthopaedic surgeon and a doctor with published knee research.
Dr Dinesh Sirisena
Consultant in Sports and Exercise Medicine · Sports medicine doctor at the London 2012 Olympic and Paralympic Games
Dr Edwin Tan
Consultant Orthopaedic Surgeon · FRCS (Edin) (Ortho) · Special interest in the knee
Dr Gerard Ee
Founder and Managing Director of The Clifford Clinic · MBBS (St George’s) · MRCS (Edin) · Published knee research
Hyaluronic acid knee injection FAQ
Yes, for mild to moderate knee osteoarthritis, especially a knee that feels stiff and creaky. It lubricates the joint, eases pain and helps you move more freely.
Relief usually starts within a week, peaks at four to twelve weeks and lasts six months or more.
Synolis VA is one 4 ml injection or three 2 ml injections a week apart. Synvisc-One is one 6 ml injection. Your doctor will advise which suits your knee.
In a head to head trial they worked equally well over six months. Your doctor will recommend one after examining your knee.
Numbing cream is applied to the skin first and the injection takes only a few minutes. The knee can feel full or sore for a day or two.
Yes. Hyaluronic acid knee injections are done under day surgery at The Clifford Surgery and are MediSave and hospital insurance claimable.
Hyaluronic acid suits a dry, stiff knee and lubricates the joint. PRP suits early to moderate osteoarthritis where you want longer relief. Your doctor will recommend one after examining your knee.
Anyone with an infection in or around the knee, or an allergy to hyaluronic acid or sorbitol.
References
- Cortet B, Lombion S, Naissant B, et al. Non-inferiority of a single injection of sodium hyaluronate plus sorbitol to hylan G-F20. A 6-month randomized controlled trial. Adv Ther 2021, 38(5), 2271-2283. doi.org/10.1007/s12325-021-01648-3
- Bruyère O, Honvo G, Vidovic E, et al. Assessment of the response profile to hyaluronic acid plus sorbitol injection in patients with knee osteoarthritis. Post-hoc analysis of a 6-month randomized controlled trial. Biomolecules 2021, 11(10), 1498. doi.org/10.3390/biom11101498
- Bruyère O, Honvo G, Vidovic E, et al. Is the rate of responders to hyaluronic acid injection for patients with knee osteoarthritis stable over time? Rheumatol Ther 2023, 10(5), 1297-1303. doi.org/10.1007/s40744-023-00573-x
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