Worried about crow’s feet and wrinkles as you age? Our skin gradually becomes damaged and aged due to ultraviolet rays, natural aging and repeated cosmetic treatments. Created in South Korea and surging in popularity, it is dubbed the ‘Skin healer of regeneration and hydration’. Rejuran strengthens the skin’s regeneration ability and replenishes the skin’s moisture, resulting in smoother, younger-looking skin.

Call us today at (65) 6532 2400 to book an appointment on any of our cosmetic services and treatments.

What is Rejuran?

Rejuran, also commonly known as Rejuran Healer, PN, PDRN Therapy, Miracle Healer Injection or Baby skin injection, increases the skin’s natural defenses by strengthening the skin barrier and filling natural and vital components in the skin’s structure. Rejuran is a skin treatment that rejuvenates the skin.

With the active ingredient - PN (polynucleotides) , Rejuran is able to increase the effectiveness of the dermal fibroblast and increase skin’s regeneration by as much as 20%. The skin regeneration is accelerated due to increase cell proliferation, hence helping in regeneration of skin and tissue.

PDRN is a chemical compound that consist of a mixture of deoxyribonucleotides polymers with chain lengths ranging between 50 and 2000 bp. PDRN has been shown to stimulate Vascular Endothelial Growth Factor VEGF which is an enzyme that is produced during pathological conditions of low tissue perfusion. PDRN acts through the stimulation of A(2A) receptors. Acute and chronic toxicity studies showed a good safety profile. PDRN has been used in hospitals for limb ischemia, impaired wound healing and burn injury. Other studies for the use of PDRN has also showed that the wound-healing process in donor sites of skin grafts had much faster rate of re-epithelialization. More importantly, these studies also showed no adverse events through the administration of PDRN.

There are several series of Rejuran. The doctors at The Clifford Clinic will analyse and recommend the best treatment for your skin condition.

Rejuran HB
Rejuran HB strengthens the skin’s regeneration ability, replenishes moisture and reduces pain

Rejuran i
Reduces wrinkles around the eyes and crow’s feet while improving elasticity

Rejuran s
Reduces scars (depressed and sunken scars), increases volume around the depressed area to make skin smooth again


  • Anyone wishing to strengthen their skin’s regeneration ability, replenish moisture and reduce pain at the same time
  • Patients who wish to rapidly increase the skin’s regenerating effect after laser treatments and rehydrate the skin after moisture lost due to laser heat
  • Patients in their 40s, or older, who wish to reduce and improve severe wrinkles due to ageing


  • Reduced fine lines and wrinkles
  • Improved skin elasticity
  • Improved Hydration
  • Improved skin tone and texture
  • Reparation of skin
  • Reduction of depressed or sunken scars
  • Improved skin regeneration and skin repair


  • Wrinkles, fine lines and crow’s feet around the eyes
  • Enlarged pores
  • Sagging skin
  • Dark eye circles or panda eyes
  • Acne scars
  • Stretch Marks

Call us today at (65) 6532 2400, Whatsapp us at (65) 8318 6332 or email us at thecliffordclinic@gmail.com to book an appointment or enquire on any of our cosmetic services and treatments.


Firstly, a topical numbing cream is administered for around 20 minutes. Rejuran is then administered under the skin using a fine needle to the affected area. The treatment process should take just around 10 minutes, depending on the size of the affected area.

Temporary swelling or visible bumps on the skins may last from a few hours to a day.

After the treatment is complete, time is required for the PDRN to take effect and repair the skin from the inside thus it takes up to a month to see any visible improvements on your skin. It is recommended to have the treatment done 3 to 4 times, every 2-4 weeks. Maintenance treatments are then recommend once every 6-9 months after the last treatment.

In order to improve results and ensure their long-lasting effectiveness, our doctors may recommend skin healing programs to complement the treatment.


While they may seem similar, Restylane SkinBoosters have different functions compared to Rejuran. Restylane SkinBoosters contain hyaluronic acid (HA) that provides hydration to the dermis layer of the skin providing long lasting moisture smoothens up pores improving the skin surface.

Rejuran however, more aggressively combats the effects of aging by actively repairing and healing damaged skin cells and reverses the signs of aging.

Both Restylane SkinBoosters and Rejuran treatments simply work in different ways to combat aging, and combining the treatments can achieve more optimal effects!


Yes most definitely. Rejuran can be easily combined with skin boosters and done together. Because the techniques of injection is exactly the same as skin boosters, the Rejuran mixture can be combined together with the skin boosters and administered simultaneously.


Yes. Some PDRNs are used for topical application, while other forms of PDRN are used in subdermal administration.