JULÄINE of Sweden in Singapore
A next generation PLLA collagen biostimulator for natural looking facial rejuvenation
JULÄINE of Sweden is a next-generation poly-L-lactic acid, or PLLA, collagen biostimulator designed to activate the skin’s own collagen production gradually. Unlike traditional dermal fillers that create an immediate volumising effect, JULÄINE works by supporting collagen regeneration over time, helping the skin appear firmer, smoother and more naturally refreshed.
At The Clifford Clinic in Singapore, JULÄINE may be considered for patients who want a subtle, progressive and natural-looking approach to facial ageing. It is especially relevant for patients who feel that their skin has become thinner, less firm, more crepey, or that lines and folds have become more visible with age.
What is JULÄINE of Sweden?
JULÄINE is an injectable PLLA collagen biostimulator developed and manufactured in Sweden by Nordberg Medical. It is part of a newer generation of regenerative aesthetic injectables that focus less on simply filling the face and more on bioactivating the skin’s own repair and collagen-building response. JULÄINE is powered by LASYNPRO microsphere technology, designed to regenerate collagen, smoothen wrinkles and tighten the skin.
The treatment works gradually. After injection, the PLLA microspheres act as a stimulus for collagen production. Over the following weeks and months, the skin may become firmer, smoother and better supported. This makes JULÄINE suitable for patients who prefer results that build slowly rather than a sudden change in facial shape.
JULÄINE is not a hyaluronic acid filler, not a skinbooster in the usual hydration-only sense, and not a laser treatment. It belongs to the category of collagen-stimulating injectables, where the aim is to improve the skin’s internal collagen support over time.
What are the ingredients in JULÄINE?
According to the official Instructions for Use, each vial of JULÄINE powder contains
- 150 mg of poly L lactic acid microspheres
- 45 mg of sodium carboxymethylcellulose
- 145 mg of non pyrogenic mannitol.
The key ingredient is poly L lactic acid, or PLLA. PLLA is a biocompatible and biodegradable material that has been used in medicine for many years. In aesthetic medicine, PLLA is used because it can gradually stimulate collagen formation. Medical summaries describe PLLA as an absorbable injectable implant that can restore volume and gradually stimulate collagen formation..
What makes JULÄINE different?
JULÄINE is designed with LASYNPRO microsphere technology that allows the product to be easy to inject, integrate smoothly into the skin and demonstrate a strong safety profile.
Earlier Nordberg Medical product information also describes JULÄINE as using high-purity PLLA, homogeneous soft microspheres, minimal aqueous residue and high standard quality control.
The microspheres are described as 20 to 50 microns in size, with controlled degradation and progressive release of high-purity L-lactic acid.
This matters because collagen biostimulators are not just about the ingredient. A good collagen biostimulator should not create obvious lumps of volume. It should support gradual tissue improvement in a controlled and balanced way.
How does JULÄINE work?
Ageing affects the skin and face in several layers. Collagen declines, skin becomes thinner, the dermis loses firmness, fat support changes and facial folds become more visible. Nasolabial folds, marionette lines, lower face heaviness and skin laxity may become more obvious as these changes progress.
JULÄINE works by placing PLLA microspheres into the appropriate tissue plane. These microspheres create a controlled regenerative stimulus. Over time, fibroblast activity increases and new collagen is produced. This new collagen provides internal support, helping to improve skin firmness, smoothness and the appearance of lines.
This is why the result is gradual. Patients should not expect JULÄINE to behave like an instant filler. There may be temporary fullness from the injected fluid immediately after treatment, but this settles. The more meaningful effect appears as collagen develops over the following weeks and months.
What can JULÄINE help with?
JULÄINE is officially intended for the correction of mild to severe nasolabial folds in adult immunocompetent individuals.
At The Clifford Clinic, JULÄINE may be assessed for concerns such as:
- Nasolabial folds
These are the lines that run from the side of the nose toward the corners of the mouth. JULÄINE may help soften these folds by supporting gradual collagen regeneration. - Loss of skin firmness
Patients who feel their skin has become thinner, looser or less elastic may benefit from collagen stimulation. - Fine lines and wrinkles
JULÄINE may help improve the appearance of lines that are related to collagen loss and skin thinning. - Early facial deflation
Patients who look tired or less supported may benefit from gradual collagen rebuilding rather than obvious filler volume. - Skin quality deterioration
JULÄINE may help improve texture, firmness and elasticity as collagen production increases. - Natural-looking facial rejuvenation
Patients who do not want a dramatic filler look may prefer the slow, progressive nature of PLLA biostimulation.
Benefits of JULÄINE treatment
The main benefit of JULÄINE is that it works through collagen regeneration rather than simple mechanical filling. This makes the treatment suitable for patients who want natural looking improvement without sudden facial change.
JULÄINE may help improve:
- Skin firmness
New collagen can improve dermal support and make the skin feel firmer. - Wrinkles and folds
Gradual collagen stimulation can soften the appearance of lines, especially where collagen loss is a major contributor. - Facial support
The treatment may help improve the look of mild tissue laxity and facial deflation. - Skin texture and elasticity
As collagen improves, the skin may look smoother and more resilient. - Natural looking rejuvenation
JULÄINE is designed to work gradually, helping patients avoid an obviously overfilled appearance. - Longer-lasting improvement
PLLA treatments are known for gradual and longer-lasting collagen stimulation compared with temporary hydration treatments.
JULÄINE versus hyaluronic acid fillers
Hyaluronic acid fillers and JULÄINE are both injectable treatments, but they are not the same.
Hyaluronic acid fillers are gel-based fillers. They provide immediate volume, contour and shape. They are useful when the goal is to lift, contour, replace volume or correct a specific hollow quickly.
JULÄINE works more gradually. It does not primarily create instant gel volume. Instead, it stimulates the skin to rebuild collagen over time. The result is slower but often more natural in appearance.
Another important difference is reversibility. Hyaluronic acid fillers can often be dissolved with hyaluronidase when appropriate. PLLA cannot be dissolved in the same way.
Book a doctor-led consultation at The Clifford Clinic, so you can understand your diagnosis, the most suitable options and what results are realistic for your skin.
Who is suitable for JULÄINE?
JULÄINE may be suitable for adults who want gradual improvement in skin firmness, nasolabial folds, wrinkles or early facial ageing. It is best suited for patients who understand that the result is progressive and that collagen stimulation takes time.
Good candidates often include patients who:
- Prefer natural-looking rejuvenation
- Do not want an obvious filler look
- Have mild to moderate facial ageing
- Have visible nasolabial folds
- Want firmer and smoother looking skin
- Are willing to commit to a treatment plan and review schedule
What happens during a JULÄINE consultation?
A consultation is important because JULÄINE is a planning based injectable. The doctor should assess the face as a whole rather than simply injecting one line.
During consultation, the doctor will usually assess:
- Facial ageing pattern
This includes folds, laxity, volume loss, skin thinning and collagen decline. - Nasolabial fold severity
The depth and cause of the fold should be assessed before treatment. - Skin thickness and texture
Thinner skin may require a more cautious treatment plan. - Previous filler or injectable history
Patients should inform the doctor about previous fillers, collagen stimulators, threads or energy-based procedures. - Medical history and safety factors
This includes allergies, autoimmune conditions, scarring tendency, medication use and history of delayed reactions. - Aesthetic goals
Some patients want softening of folds, while others want firmer skin or a more refreshed look.
What happens during the treatment?
JULÄINE is injected by a trained healthcare professional. It should only be administered by appropriately trained healthcare professionals who are qualified or accredited according to national law.
Before treatment, the skin is cleaned and disinfected. Numbing cream or local anaesthetic may be used depending on the treatment plan. JULÄINE is then injected into the appropriate tissue plane using a technique chosen by the doctor.
After injection, the area may be massaged to help spread the product evenly. The product’s Instructions for Use describe a massage after completion of the injection to help the product spread more evenly.
The treatment is usually performed in a clinic and does not require general anaesthesia. Patients may experience temporary swelling, redness, tenderness or bruising after treatment.
When will I see results?
JULÄINE results are gradual. Immediately after treatment, there may be some fullness due to the injected suspension and swelling. This is not the final result and usually settles.
The true effect appears as collagen production develops. Patients may begin to notice improvement over several weeks, with more visible changes over the following months. This slow improvement is one of the reasons JULÄINE can look natural. It does not suddenly change the face overnight.
The official JULÄINE website emphasises gradual collagen regeneration and long lasting collagen renewal, rather than quick or dramatic transformation.
How many sessions are needed?
The number of sessions depends on the patient’s skin condition, fold severity, collagen response and treatment goals.
The product Instructions for Use state that treatment can be repeated after 2 to 4 weeks, and that after a maximum of three treatment sessions, further filling of the nasolabial fold may not be necessary because the folds gradually fill thereafter.
In clinical practice, a doctor may recommend a staged approach. This avoids overcorrection and allows collagen stimulation to develop naturally. Some patients may need fewer sessions, while others may need a more structured plan.
JULÄINE aftercare
After JULÄINE treatment, patients should keep the treated area clean, avoid unnecessary pressure or aggressive facial massage unless instructed, and follow the clinic’s massage and aftercare protocol.
It is advisable for patients to avoid sunlight and UV light exposure until swelling and redness have disappeared, and to avoid very high or very low temperatures.
Patients should avoid intense exercise, alcohol, sauna, facial treatments and heat-based treatments for the period advised by the doctor.
Makeup should usually be avoided immediately after injection to reduce contamination risk.
If significant pain, skin colour change, visual symptoms, increasing swelling or signs of infection occur, patients should contact the clinic urgently.
Book a JULÄINE consultation in Singapore
JULÄINE of Sweden is suitable for patients who want a gradual, collagen stimulating approach to facial rejuvenation. It may help improve nasolabial folds, skin firmness, wrinkles and overall facial support in a natural looking way.
At The Clifford Clinic, JULÄINE treatment begins with a consultation to assess your skin, facial structure, ageing pattern and treatment goals. A personalised plan can then be created to determine whether JULÄINE should be used alone or as part of a broader rejuvenation protocol.
Frequently Asked Questions
JULÄINE contains PLLA microspheres rather than a hyaluronic acid gel. The injected suspension may create temporary fullness at first, but the main result comes from collagen regeneration over time. This is why patients should expect gradual improvement rather than an instant final result.
Microsphere design affects how evenly the product disperses, how smoothly it integrates into tissue and how predictable the collagen response may be. Nordberg Medical describes JULÄINE as using uniform microspheres and high purity PLLA, with 20 to 50 micron microspheres and controlled degradation over time.
It depends on where the fillers were placed, how much product is present and whether there are any delayed swelling or lump issues. JULÄINE should not simply be layered over existing filler without assessment. The doctor may recommend waiting, dissolving selected old filler, or planning treatment in a different layer.
PLLA cannot be dissolved like hyaluronic acid filler. It also continues to stimulate collagen after treatment, so overcorrection may become more obvious later. A conservative staged plan allows the doctor to build results safely and avoid an overfilled or uneven appearance.
No. JULÄINE can improve collagen support, firmness and folds, but it does not surgically reposition tissue or remove excess skin. Patients with significant sagging may need a lifting procedure, HIFU, RF tightening, or surgery. .