Polynucleotide Treatment for Knee Osteoarthritis and Cartilage Wear at The Clifford Clinic
Knee pain can limit stairs, squats, long walks, and sports. When symptoms persist despite physiotherapy and strengthening, a doctor guided knee injection may be considered as part of a broader plan.
Conjuran is a polynucleotide intra articular injection used for knee osteoarthritis symptoms and cartilage wear, aimed at improving comfort and function so you can move better and train more consistently.
Book a consultation at The Clifford Clinic to assess whether Conjuran is suitable for your knee, and to discuss alternatives such as hyaluronic acid injections for knees and platelet rich plasma injections, along with other injection options where appropriate.
Conjuran is a polynucleotide knee injection delivered into the knee joint. Polynucleotides are DNA fragments used in medical applications and, in knee care, they are used as an intra articular injectable option for osteoarthritis symptoms and cartilage related irritation.
Conjuran is often discussed alongside viscosupplementation because it is used for joint lubrication support and to promote a more favourable joint environment, depending on the clinical context.
Conjuran is most commonly considered for knee osteoarthritis symptoms and cartilage wear, especially when pain is activity related and affects daily function.
You may be suitable if you have:
Persistent knee pain that fits an osteoarthritis pattern
Early to moderate cartilage wear on imaging
Pain that limits stairs, prolonged walking, squats, or returning to exercise
A preference for a non surgical option while continuing rehabilitation
Conjuran is generally not used as a primary treatment for:
Meniscus tears causing mechanical locking
Significant ligament instability
Suspected infection or unexplained swelling
End stage osteoarthritis where surgical planning may be more appropriate
A consultation is important because knee pain can come from the joint, the meniscus, tendons, or referred sources.
Conjuran is commonly described as working in two practical ways.
First, it may support joint lubrication and reduced friction, which can help ease movement related discomfort.
Second, it may help create a more supportive joint environment for symptom control in selected cases, which can make it easier to participate in strengthening and physiotherapy.
The goal is not to replace rehabilitation. The goal is to reduce pain enough to help you rebuild knee capacity and improve function.
Many may ask if Conjuran is the same as a knee gel injection.
Hyaluronic acid viscosupplementation is typically described as restoring the lubricating properties of joint fluid to reduce friction and improve movement comfort.
Conjuran polynucleotide injections are a different injectable category, often discussed as a viscosupplement like option with additional proposed tissue supportive effects.
The right choice depends on your symptoms, imaging findings, severity, activity goals, and what you have already tried.
If you are deciding between Conjuran, hyaluronic acid, and PRP for knee symptoms, start with the pattern of your pain, your imaging, and your goals.
Hyaluronic acid is often considered when symptoms are mainly osteoarthritis related, such as activity pain with stiffness, and the aim is to improve joint lubrication and reduce friction so walking and stairs feel easier.
Conjuran is usually discussed in a similar osteoarthritis and cartilage wear context, but as a polynucleotide option that some clinicians use when they want a viscosupplement-type approach with additional proposed tissue-supportive effects.
PRP is usually considered when the goal is more biologic signalling rather than lubrication, and it is often discussed for earlier stage cartilage wear, inflammatory type flares, or cases where you want an option derived from your own blood. It may also be considered when pain seems to involve soft tissue and synovial irritation rather than purely mechanical friction.
The most practical way to choose is to match the injection to the dominant driver: if your knee behaves like a “dry and creaky” osteoarthritis pattern, HA or Conjuran may be the first discussion, while if your knee has more reactive swelling or you are aiming for a biologic approach, PRP may be discussed.
Whatever the choice, the injection should be paired with a structured rehab plan, because long-term improvement still depends on rebuilding strength and controlling load.
Don’t let your knee pain slow you down. Take the first step toward stronger, pain-free movement today.
Your appointment at The Clifford Clinic is doctor led and structured around diagnosis and suitability.
We typically cover:
A detailed symptom map including what triggers your pain
Focused knee examination including range of motion and functional loading
Review of imaging when needed such as X ray, ultrasound, or MRI
Discussion of options including Conjuran, hyaluronic acid, and other injection approaches
A clear plan for aftercare and rehabilitation
If an injection is appropriate, we explain expected timelines, realistic outcomes, and safety considerations.
A Conjuran knee injection is performed in clinic using sterile technique. The typical flow includes:
Skin preparation and cleaning
Knee positioning for safe access
Injection into the joint space
Short observation period and aftercare instructions
Ultrasound guidance may be used when it meaningfully improves accuracy, depending on your anatomy and clinical findings.
Most patients describe brief pressure or stinging, followed by a temporary sense of fullness or mild soreness.
Don’t let your knee pain slow you down. Take the first step toward stronger, pain-free movement today.
Protocols vary by clinical judgment and by the product plan. Many PN knee treatment schedules are delivered as a short course of sessions, then reviewed based on response and functional improvement.
During consultation, we will outline a recommended plan and the criteria we use to decide whether to continue, adjust, or stop.
Most patients can return to light daily activities shortly after the injection. We usually advise:
Keep activity comfortable for the first few days
Avoid high impact loading such as running, jumping, or heavy leg training briefly, based on your knee status
Restart strengthening and physiotherapy in a structured way
Track progress using functional markers such as stairs, walking tolerance, and training capacity
If you develop increasing warmth, swelling, fever, or worsening pain, you should contact the clinic for assessment.
Patients often consider Conjuran because it is:
A non surgical injection option for osteoarthritis symptoms and cartilage wear
A way to reduce pain and improve function in selected cases
A supportive step that can improve tolerance for rehabilitation
Limitations to understand:
Response varies between individuals
It does not repair large ligament tears or meniscus locking problems
It is not positioned as a guaranteed solution
Long term outcomes depend heavily on strengthening, load management, and overall joint health
At The Clifford Clinic, knee injection care is built around diagnosis accuracy and safe delivery.
Doctor led assessment
Your knee is assessed to determine the most likely pain generator, and injection choice is matched to your diagnosis and goals.
Experience with knee pain evaluation and injection planning
Our doctors manage musculoskeletal and sports related knee presentations, and perform joint injections as part of structured care plans. Ultrasound guidance is used when appropriate to support accuracy and safety.
Clear rehabilitation pathway
We provide staged guidance so you know how to return to walking, gym training, and sport without repeated flare ups.
Transparent communication
We focus on realistic outcomes, and we discuss alternatives and limitations so you can decide with clarity.
No. PRP uses components from your blood. Conjuran is a polynucleotide intra articular injection.
Some patients notice gradual improvement over weeks. The timeline varies depending on osteoarthritis severity, activity load, and rehabilitation.
Light walking is usually fine. Return to strenuous exercise should follow your doctor’s advice.
No. Strength and load management remain central. Injections are usually used to support your ability to rehabilitate.
If you are exploring Conjuran knee injection in Singapore, book a consultation at The Clifford Clinic.
We will assess your knee, confirm suitability, and discuss Conjuran alongside other options such as hyaluronic acid viscosupplementation then guide you through aftercare and rehabilitation planning.
