Author: Dr Branden Seow
What is Nucleofill?
Nucleofill is increasingly becoming more popular as an anti-aging method as it is easy to administer with minimal downtime. Nucleofill is a polynucleotide-based injectable bio-stimulant that stimulates the production of collagen and elastin in the skin’s dermis. The polynucleotide from Nucleofill is derived from Salmon DNA.
Nucleofill is considered to be a biostimulator. Biostimulators are bio-compatible (compatible with the human body) synthetic materials that stimulate fibroblasts (collagen producing cells) in the dermis to increase collogen and elastin production — tightening and lifting the skin.
Polynucleotides are substances used to make DNA as well. The polynucleotides in Nucleofill are bio-engineered to stimulate receptors found on the surface of fibroblast cells in the skin’s dermis. The stimulation of these cell receptors triggers the activation of fibroblasts into type I collagen and elastin producing myofibroblast cells, which in turn firms and lifts the skin to reduce sagging and smoothen out wrinkles. Restructuring of the dermal matrix via new collagen and elastin production ensures that the root cause of skin laxity is addressed, allowing for long-lasting and deep rejuvenation of the skin.
Antioxidant and hydrating effect
In addition, Nucleofill has an antioxidant effect as well. Nucleofill removes free radicals by acting as a free radical scavenger. The antioxidant effect from Nucleofill allows it to protect collagen fibers, newly rejuvenated skin, and the skin’s epidermis from further damage by free radicals.
Also, polynucleotides, the main ingredient that constitutes Nucleofill, have a high affinity for binding with water. The binding of polynucleotides to water molecules in the dermal matrix allows for deep and lasting hydration as well as hydro lifting of the skin, giving the skin a firm and moisturized feel.
Who is suitable for Nucleofill treatment?
Nucleofill treatment is suitable for anyone who is
- looking for a long-lasting anti-aging treatment
- suffers from acne scars
- has dry or dull skin
- bothered by visible stretch marks on their skin
What results can I expect from Nucleofill?
- Firmer and youthful looking skin
- Improved skin elasticity and reduced sagging
- Increased collagen production for sustained skin firmness
- Improvements in the appearance of fine lines and wrinkles
Is Nucleofill a filler?
No, Nucleofill is not a filler. Nucleofill is made up of polynucleotide, while a filler is typically made of hyaluronic acid (HA).
Fillers can directly address clear-cut volume loss issues on the face that are associated with aging. For example, with aging, the temples can be more sunken, or the mid-cheek area can be flatter than before. Fillers can help to restore the temples and cheeks to its original volume. At the same time, fillers can help to reshape the nose and the chin. Nucleofill can perform none of these.
While Nucleofill can help individuals seeking to rejuvenating and hydrate the skin, the volumizing effect of the Nucleofill cannot be compared to a HA filler. While Nucleofill can help in one’s anti-aging effort, it will not to be able to restore volume loss adequately.
Nucleofill is compatible with the use of dermal fillers and can complement each other.
Nucleofill Vs Profhilo, what is the difference?
The main ingredient in Profhilo is pure concentrated hyaluronic acid while Nucleofill is a bio-stimulant gel made from polynucleotides.
Hyaluronic acid (HA) is a naturally occurring compound found in skin, muscle, and joints. The ability of HA to readily bind to water molecules and HA being able to draw up to 1000 times its weight in water, makes Profhilo ideal for providing excellent hydration to the skin. The high concentration of pure HA in Profhilo is also able to encourage bio-remodeling via inducing the body’s natural healing response to increase collagen and elastin by stimulating fibroblast cells, improving the skin’s structure, elasticity, and firmness, giving the skin a plump and dewy look.
While Nucleofill is also able to bind to water to provide deep hydration to the skin, Nucleofill does not draw in as much water as Profhilo. Thus, Nucleofill may be more suitable for areas of the face with thinner skin where excessive water retention is undesirable.
Unlike Profhilo, Nucleofill is a bio-stimulant capable of activating fibroblast cells into type I collagen and elastin producing myofibroblasts by directly stimulates specific receptors on the fibroblast cells, achieving bio-regeneration and rejuvenation of the skin due to the sustained and increased production of collogen by myofibroblasts. Results for Nucleofill also typically last longer than Profhilo.
In summary, due to the intense hydrating effect from Profhilo, Profhilo tends to give a better glow. These two treatments are compatible with each other and can be combined for better results.
Nucleofill Vs Rejuran, what is the difference?
Nucleofill and Rejuran are made from the same substance – polynucleotide. As such, the properties between the two products are very similar. Both can help enhance the production of collagen and elastin in our skin. Nucleofill has a higher concentration of polynucloetide than Rejuran Healer.
These two treatments are compatible with each other and can be combined for better results. The administration of Nucleofill tends to be deeper into the skin while Rejuran is more superficial.
Nucleofill Vs Botox, what is the difference?
Botulinum toxin, often shortened to Botox, is a neurotoxic protein made by the bacterium Clostridium botulinum. It inhibits the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing muscle paralysis. In other words, Botox works better on dynamic wrinkles, wrinkles that are caused by movement from the muscle.
Static wrinkles are caused by the loss of skin collagen as one ages. Nucleofill, with its bio stimulant property, can help to stimulate collagen production in the skin. As such, Nucleofill can help with static or fine wrinkles.
What can I expect during the treatment?
After a detailed consultation with our doctors at The Clifford Clinic, a layer of numbing cream will be applied onto the area for 30 minutes prior to the injections.
5 to 7 injection points, depending on if a 5-point technique or 7-point technique is used, will be marked out on each side of the face to allow Nucleofill to be injected into the dermal matrix.
Is Nucleofill painful?
Topical aesthetic cream will be applied to numb the treatment area prior to the procedure.
How frequently should I undergo a Nucleofill treatment?
It is recommended to undergo a series of 3-4 treatments every 2-4 weeks for the best results.
How long can the results of Nucleofill last?
Results are expected to last up to 1-2 years.
Who is not suitable for Nucleofill treatment?
- Pregnant or breastfeeding individuals
- Patients with underlying autoimmune diseases or coagulation disorders
How much Nucleofill is contained in each injection?
Each syringe of Nucleofill contains 2mls of the product.