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Gouri - The First Injectable Liquid Polycaprolactone (PCL)

What is GOURI and what is PCL?

DEXLEVO, a company from South Korea, had invented the world’s first liquid polymer filler, also known as GOURI. GOURI is made of liquid polycaprolactone (PCL), and the liquid state makes GOURI injectable.

PCL can be degraded by the human body and hence, its popular use as an implantable biomaterial.

PCL has been approved by the Food and Drug Administration (FDA) in specific applications used in the human body such as drug delivery device and sutures.  There is also a PCL-based microsphere dermal filler belonging to the collagen stimulator class, also known as Ellansé.

By stimulating collagen product, PCL-based products can reverse facial ageing features such as volume loss and contour laxity, providing a good long-lasting natural effect.

As such, GOURI, also made of PCL, has anti-aging properties and is biodegradable as well. Being in a liquid form, GOURI can spread evenly throughout the entire face and hence promotes natural skin collagen synthesis, which helps your skin age more gracefully.

GOURI VS Dermal Fillers

GOURI is developed using DEXLEVO’s Caollagenesis-Enabled Solubilized Active and Biodegradable Polymer Technology (CESABP) technology that enables regeneration of natural skin collagen without the use of microparticles.

There are hyaluronic acid (HA)- base fillers and PCL-base fillers. Dermal fillers may also have a regenerative impact on the collagen. Due to the nature and shape of particles, dermal filler cannot be injected evenly into the skin. As a result, these fillers are limited to focal areas only. For example, we can use Ellanse (a PCL-based filler) to fill up certain types of acne scars.

As such, GOURI is more for a generalized effect while dermal fillers are more targeted and focused on areas that have a specific volume defect.

GOURI VS Profhilo

While both GOURI and Profhilo only require 10 injection points, they are made of different substances. GOURI is made with fully solubilized liquid form of PCL while Profhilo is made from Hyaluronic Acid (HA).  Profhilo can help with hydrating the skin as well as giving a gentle glow to the skin, while GOURI helps by giving a gentle lifting effect to the face in a generalized fashion.

Benefits of GOURI:

  • Fewer injection points, as compared to other types of skin injectables, except Profhilo which requires the same injection points
  • Transforms into a three-dimensional matrix and encourages fibroblasts formation
  • Stimulates new collagen production
  • Increases skin elasticity and rendering a gentle facelift

Treatment Procedure

GOURI  is carefully injected into 5 specific points on each side of the patient’s face. A layer of numbing cream will be applied prior to the procedure.


Anyone who is interested in anti-aging and feels there is generalized volume loss on the face is suitable for GOURI. As everyone has unique skin condition, please consult the doctor before commencing treatment. 

Typically, the first visual benefits are visible after 1-2 weeks, up till a month for some patients.

It depends on each individual. PCL generally can last for about 12 month in the body.

The current protocol recommends 3 sessions at 4 weeks interval for good results.

Yes, you can supplement GOURI treatment with other treatments like skin boosters and Botox.