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Cystic VS Hormonal Acne: What It Is & Best Treatment Options

Hormonal cystic acne on the cheek, jawline and chin, side view, cystic vs hormonal acne

Cystic VS Hormonal Acne: What It Is & Best Treatment Options

Breakouts and problematic skin is something that commonly plagues those in their teens; however, can also pop up during adulthood long after puberty ends. And unfortunately, adult acne is far more persistent. Deep, painful lumps that keep returning are the severe form; the clinic’s cystic acne treatment page sets out what stops them.

A 2018 review published in the Clinical, Cosmetic and Investigational Dermatology reported a dramatic rise in adults dealing with acne, with factors such as stress, pollution and hormonal birth control being the most common reasons.

Acne sufferers will know that acne does not discriminate – while the occasional pimples are normal (almost everyone has had mild acne at some point) and not as frustrating to deal with, cystic and hormonal acne are a different ball game altogether.

It can also be hard to decipher whether those blemishes you have are hormonal or cystic –  which is why we have prepared an article to help you figure out the differences as well as your best treatment options.

Cystic VS Hormonal Acne

Cystic acne occurs when a pimple becomes trapped and infected deep within the dermis. Appearing predominantly on the face and T-zone area, as well as the chest, back and shoulders, the types of blemishes that you see in cystic acne are typically larger, more painful, pus-filled, and much harder to get rid of.

The biggest cause of cystic acne is the result of dietary sensitivities and an overproduction of sebum. In fact, dairy is one of the main causes of cystic acne breakouts. If you have a parent who has dealt with cystic acne, chances are, you will develop it too.

On the other hand, hormonal acne is seen whenever there is significant hormonal changes (e.g. pregnancy, menopause, prolonged periods of stress). Both women and men can experience hormonal acne – reason being – androgens represent the most important of all hormones in regulating sebum production. When hormone levels fluctuate, this can stimulate sebaceous gland activity, which in turn, increases oil production.

The most common places where hormonal acne appears are the chin, neck and jawline. One of the surest signs of hormonal acne is when it manifests in a cyclical pattern, much like a women’s menstrual cycle.

How hormones cause hormonal cystic acne

Androgens are the male-type hormones, such as testosterone, that both men and women make. They are the main hormones behind acne. They make the oil glands grow and produce more oil. Female hormones such as oestrogen help keep oil in check. When the balance leans towards androgens, the glands make too much oil. Pores block, acne bacteria grow and deep, inflamed cysts form. Diet, skincare products, the monthly cycle and stress can all upset this balance. Stress can make acne worse, and the stress hormone cortisol may add to androgen activity and swelling. In surveys, between almost half and two in three women with acne say it gets worse around their period, when the balance tips towards androgens. Adult acne is more common in women than in men at every age. About half of women in their 20s have acne. Cystic acne is more common in people with oily skin, in teenagers, and in adults with a hormone imbalance. Men more often get severe cysts, including on the back, chest and shoulders. Women more often get cysts on the lower half of the face.

The main similarity between cystic and hormonal acne is that both of them are hormonally mediated. The only difference is, cystic acne can also be caused by a plethora of factors including genetics, certain medications and high humidity levels.

Cystic acne is considered to be the most serious type of acne and is the most prone to scarring. In both cases, picking at your blemishes is never an option – especially for cystic acne, constant picking can lead to consequences such as scarring and hyperpigmentation, both of which will require a different treatment plan by themselves.

Once you begin to understand the cause of your breakouts, it becomes a lot easier to determine the best option for treatment. Although cystic acne can improve over time, they often do not leave on their own. Working with an experienced aesthetic doctor is your best line of defence if you suspect you have the condition.

Best treatment options

Both cystic and hormonal acne do have distinct differences, but they may not be exclusive to one another.

Skin doctors often recommend topical retinoids as the first line of therapy for mild to moderate acne. Oral therapies are also often prescribed to help reduce the level of androgens that cause hormonal acne, such as spironolactone for women and isotretinoin – a form of oral vitamin A that has been shown to improve acne symptoms in more than eight in ten patients within four to six months.

The biggest downside to oral therapies is that they can take up to 6 months to see any significant improvements. While they can be successful in improving stubborn cystic acne, they often come with various side effects, including dryness of the skin, change in mood, and joint or muscle pains in the case of isotretinoin.

The fear of antibiotic resistance can also prove to be an issue when trying to find a suitable solution to treat cystic and hormonal acne in the long run.

Thankfully, there are plenty of acne treatment options available that do not involve unwanted side effects, such as laser therapy and AGNES. There are also laser treatments that can be used to effectively destroy the P.acnes bacteria while simultaneously encouraging the skin to heal such as V-beam and Q-switch.

Best treatment for hormonal cystic acne

Creams such as retinoids, benzoyl peroxide and azelaic acid suit mild to moderate acne and help keep the skin clear afterwards. Cysts sit deep in the skin, so creams alone rarely reach them, but they still help alongside tablets. Antibiotic tablets help more severe acne, but acne often comes back when they stop. They are not for long-term use, because bacteria can become resistant. Tetracycline antibiotics such as doxycycline are not used in pregnancy, because they can stain the baby’s teeth and slow bone growth. For adult women, low-dose spironolactone blocks androgens at the oil gland. In a trial in adult women with moderate acne, it worked better than doxycycline at six months. Spironolactone is not used in pregnancy. Hormone treatment also suits women whose cysts flare with their cycle, and it can delay the need for isotretinoin. Isotretinoin is the strongest treatment for severe cystic acne. Tell the doctor at once about headaches or low mood during the course. Isotretinoin cannot be taken in pregnancy. Our doctors advise waiting at least one year after the final dose before trying to conceive. AGNES, AviClear and Gold PTT treat the oil glands and pair well with tablets. Gold PTT uses no medication, which is why it is the acne treatment our doctors offer during pregnancy. Our doctors have more than 40 years of combined experience in acne care. See hormonal acne treatment and cystic acne treatment.

Acne doesn’t have to last forever


At the end of the day, everyone’s acne is considered unique. Both cystic and hormonal acne are tough to handle alone, and they aren’t as easy to treat as blackheads and whiteheads.

Most patients with cystic and hormonal acne are often dealing with painful cysts that are found deeper within the skin’s surface and cannot be resolved with just topical treatments alone.

Reducing sebum production is a key goal of any acne treatment as decreasing the levels can result in lowered levels of bacteria – effectively cutting off any possible inflammation or infection. Offering the best acne spot treatment in Singapore, The Clifford Clinic specializes in dealing with recurring, hard-to-treat cystic acne and employs an active, combination treatment approach to tackle it at its root.

Our aesthetic clinic offers AGNES – a long-lasting solution to banish pimples and stubborn breakouts by employing a tiny microscopic needle attached to a radiofrequency current to target overzealous oil glands and shut it down.

The treatment does not come with any side effects and patients can expect an improvement of close to nine in ten in their acne condition after three sessions. Minimal discomfort, downtime, redness or scabbing – and most importantly, no recurrence whatsoever!

Another innovative, long-lasting cystic acne treatment is our Gold Photothermal Therapy (PTT) treatment that delivers gold nanoparticles into the pores and glands to modify the pores and sebaceous glands responsible for acne and reduce sebum production.

With no downtime, no anaesthesia and no side effects – patients can expect an improvement in their acne around 6 weeks after the last treatment. In fact, our clinic is the first to introduce both AGNES and Gold PTT treatments in Singapore! Combined with over 20 years of experience in helping patients achieve acne-free skin, this makes us prime to employ the treatment in a safe and effective manner.

We are also proud to offer over 10 different acne treatments to date, including a variety of laser therapies such as the Fractional CO2 and Fraxel Dual laser, as well as a range of doctor-approved medications, creams and skincare products.

Our aesthetic clinic also offers acne scar treatments including Rejuran Healer that boosts DNA repair and induces collagen production to help heal any residual scarring left behind by cystic acne, as well as specialize in hair transplant procedures that are all focused on rebuilding your confidence and self-esteem!

If you have noticed that over-the-counter treatments do nothing for you and are ready to take the next step to bid goodbye to your acne – book a consultation with us today!

Cystic vs hormonal acne FAQ

Is cystic acne hormonal?

Often, yes. Androgens drive the oil glands in both, so cystic acne and hormonal acne overlap. Cysts on the chin and jawline that flare before a period are usually hormonal. Cystic acne can also come from genes, some medicines and humid weather, so not every cyst is hormonal.

Is hormonal acne always cystic?

No. Hormonal acne can be small red spots, blackheads and whiteheads as well as deep cysts. In adult women it is often mild to moderate, with closed whiteheads and sore spots on the lower face.

References
  1. Zouboulis CC, et al. Sexual hormones in human skin. Horm Metab Res 2007, 39(2), 85–95. doi.org/10.1055/s-2007-961807
  2. Stoll S, et al. The effect of the menstrual cycle on acne. J Am Acad Dermatol 2001, 45(6), 957–960. doi.org/10.1067/mjd.2001.117382
  3. Geller L, et al. Perimenstrual flare of adult acne. J Clin Aesthet Dermatol 2014, 7(8), 30–34. PubMed 25161758
  4. Chiu A, et al. The response of skin disease to stress, changes in the severity of acne vulgaris as affected by examination stress. Arch Dermatol 2003, 139(7), 897–900. doi.org/10.1001/archderm.139.7.897
  5. Collier CN, et al. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol 2008, 58(1), 56–59. doi.org/10.1016/j.jaad.2007.06.045
  6. Dréno B, et al. Adult female acne, a new paradigm. J Eur Acad Dermatol Venereol 2013, 27(9), 1063–1070. doi.org/10.1111/jdv.12061
  7. Dréno B, et al. Efficacy of spironolactone compared with doxycycline in moderate acne in adult females, the FASCE study. Acta Derm Venereol 2024, 104, adv26002. doi.org/10.2340/actadv.v104.26002
  8. Reynolds RV, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 2024, 90(5), 1006.e1–30. doi.org/10.1016/j.jaad.2023.12.017
  9. Doxycycline hyclate tablets, US prescribing information. DailyMed.

Dr Gerard Ee

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Dr Gerard Ee

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Dr Gerard Ee is the Founder and Managing Director of The Clifford Clinic in Singapore. He earned his medical degree from St George's University of London and built his surgical experience across the Singapore General Hospital, National University Hospital, and Mount Sinai Hospital in New York. He holds Membership of the Royal College of Surgeons (Edinburgh) and a Postgraduate Diploma in Dermatology (Cardiff), and is fully accredited in aesthetic procedures including botulinum toxin, fillers, lasers, and light therapies. A strong advocate of minimally invasive, natural-looking results, Dr Ee has published in several medical and scientific journals and presented his research in cities including Taipei, Las Vegas, and London.

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